https://www.ceesdekker.net - An Overview
https://www.ceesdekker.net - An Overview
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‘Yes, that is definitely about correct. I seek for a physical knowledge of Organic units within a base-up way. I do think you may distinguish a few lines of investigation in my team at this time. The very first worries chromosome composition: How would you get yourself a metre-lengthy DNA polymer folded and organised in this type of microscopic mobile? Now we have created visualisation tactics that make it possible for us to check how, as an example, SMC proteins loop DNA (online video on Youtube) in order to Develop up chromosomes.
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Dynamics of initiation, termination and reinitiation of DNA translocation because of the motor protein EcoR124I
Our function was swiftly followed up by Other individuals, most notably by Phaedon Avouris and colleagues at IBM, who in October 1998 revealed their results on transistors constructed from solitary- and multi-walled carbon nanotubes in Utilized Physics Letters.
2015, discovery that condensin is actually a extremely versatile protein structure; and first detection of DNA knots applying nanopores
Experimental stage diagram of negatively supercoiled DNA calculated by magnetic tweezers and fluorescence,
Many associated developments adopted, in which our team set up different transistor variants for example single-electron transistors at place temperature and intramolecular nanotube junctions that acted as rectifying diodes, and coupled numerous transistors into smaller proof-of-basic principle electronic circuits.
Studying DNA loop extrusion by SMC proteins for chromosome architecture with one-molecule assays.
Knowledge essential procedures regulating the spatial and dynamic organisation with the DNA in Stay cells.
‘The fantastically refined way where aspects in nature function never ceases to amaze me. If we clear up the puzzle of how existence came into becoming, I expect that my amazement within the complexity of development can have elevated and with it my awe for the greatness in the Creator.’
An integrated microfluidic platform for quantifying drug permeation across biomimetic vesicle membranes
Several new phenomena had been discovered, and he and his exploration group established a number one situation On this discipline of exploration. Dekker and his research group discovered new physics of nanotubes together with explored the feasibility of molecular electronics. In 1998, they had been the main to create a transistor based on an individual nanotube molecule.
Visualization of unstained DNA nanostructures with Superior in-emphasis transmission electron microscopy procedures
Supercoiling-dependent DNA binding: ceesdekker.net quantitative modeling and applications to bulk and one-molecule experiments